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Question #113440
The Question
Given below are two statements: one is labelled as Assertion (A) and the other is labelled as Reason (R).
Assertion (A): During the metastasis of a carcinoma (epithelial cancer), oncogenic transformation induces the breakdown of adhering junctions and the loss of cellular polarity. Reason (R): Activation of cellular oncogenes (c-onc) abolishes the property of contact inhibition, driving the cells to lose tissue-level coordination and acquire a disorganized, migratory phenotype.
In the light of the above statements, choose the most appropriate answer from the options given below:
Options
- A.
Both (A) and (R) are correct and (R) is the correct explanation of (A).
- B.
Both (A) and (R) are correct but (R) is not the correct explanation of (A).
- C.
(A) is correct but (R) is not correct.
- D.
(A) is not correct but (R) is correct.
Check Your Answer
Correct Answer
Step-by-Step Solution
Explanation
How the Examiner Thinks
Regulatory_Failure
Understand how NOT, EXCEPT, and logical constraints are used to manipulate exam results.
Concepts Behind This Question
Level of Organization vs. Germ Layers|Oncogenes vs Proto-oncogenes|Epithelial Junctions Polarity
Why This Question Is Tricky
Examiner Levers
Logical Assertion
Tests the causal relationship between two true statements.
Difficulty Boost : +4Common Mistakes
Conceptual Pivot: Integrating 'Structural Organization' with 'Cancer Biology'.
A common misconception among NEET aspirants is limiting 'contact inhibition' strictly to the cessation of mitosis.
In reality, contact inhibition is physically mediated by cell-cell adhering junctions.
When oncogenes abolish contact inhibition, the structural dissolution of these junctions is exactly what permits the loss of polarity and subsequent metastasis.
Quick Facts About This Question
Question Information
| Subject | Biology |
| Chapter | Animal Kingdom - Class 11 |
| Concept | Level of Organization vs. Germ Layers |
| Difficulty | 8 |
| Cognitive Load | 5 |
| Target Solve Time | 120 sec |
| Access | Free |